INDUCED ARTHRITIS AFFECTS TESTES OF WHITE RATS
Keywords:
AIA induction, hyaluronidases, Morphometric-stereological, spermatogenic cycle, AIA group, prostate.Abstract
In the testes, AIA promoted histopathological changes characterized by an increase in the percentage of abnormal tubules and reduction in the height of the seminiferous epithelium, daily production of spermatozoa, and cellular proliferation. In the prostate, AIA decreased the luminalvolume of the secretory ducts. In condition of androgenic deprivation due to the orchiectomy, AIA induced proliferation of the prostatic epithelium.
References
1. Bruot BC & Clemens JW. (1987) Effect of adjuvant-induced arthritis on serum luteinizing hormone and testosterone concentrations in the male rat. Life Sci 41, 1559–1565.
2. Bruot BC & Clemens JW. (1992) Regulation of testosterone production in the adjuvant-induced arthritic rat. J Androl 13, 87–92.
3. Bupp MRG & Jorgensen TN. (2018) Androgen-induced immunosuppression. Front Immunol 9, 794.
4. Carageorgiou HK, Stratakis CA, Damoulis PD, Varonost DD, Messari ID, Sideris A & Sfikakis AP. (2005) Reversible plasma testosterone levels reduction after gentamicin administration and Freund’s Adjuvant Arthritic in Rats. Indian J Physiol Pharmacol 49, 443–448.
5. Choy EHS & Panayi GS. (2001) Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 344, 907–916.
6. Chung JI, Barua S, Choi BH, Min BH, Han HC & Baik EJ. (2012) Antiinflammatory effect of low intensity ultrasound (LIUS) on complete Freund’s adjuvant-induced arthritis synovium. Osteoarthritis Cartilage 20, 314–322.
7. Clemens JW & Bruot BC. (1989) Testicular dysfunction in the adjuvantinduced arthritic rat. J Androl 10, 419–424.
8. Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD & Tanasescu R. (2010) Extra-articular manifestations in rheumatoid arthritis. Maedica 5, 286– 291.
9. Costa CFP, Gobbo MG, Taboga SR, Pinto-Fochi ME & Goes RM. (2016) Melatonin intake since weaning ameliorates steroidogenic function and sperm motility of streptozotocin-induced diabetic rats. Andrology 4, 526–541.
Published
Issue
Section
License
Copyright (c) 2025 Teshayev Sh., Khabibullayev T. (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
All Rights Reserved.
